. It has therefore been suggested that Vav1 acts as a signal transducer .
In this scenario, the absence of Vav1 expression should result in the blockade of downstream Itk .
Itk-deficient cells have been used to show the significance of .
Using various Vav1 expressing cell lines, it was found that Vav1 increases recruitment of PLC .
Vav1-mediated recruitment of PLC to FcRs requires ITAMs and Src family kinases .
It has been shown that Vav1 recruits the phosphatase SHP2 to Vav1-activated ITAMs. This recruitment is essential for SHP2 activity .
It has also been shown that SHP2 promotes actin polymerization by regulating the actin-nucleating Arp2/3 complex .
Possible roles
In the absence of Vav1 expression, the activity of downstream Itk is blocked. This includes chemokine signaling, which is highly dependent upon Itk activity. If the expression of Vav1 is lacking, activation of PLC is blocked.
Vav1 is active in T cells where Itk is also active, but it is not essential for Itk-dependent functions .
In B cells
In the B cell, the function of Vav1 is less clear. In B cells, the Itk-PLC 1 pathway is important for integrin-mediated signal transduction, chemotaxis, and phagocytosis.
In macrophages
In macrophages, Vav1 and PLC 1 interact through the ITAM domain.
Interactions
Vav1 has been shown to interact with:
CBL,
Cbl-b,
Cbl-c,
C-Fes,
ITK,
JAK1,
JAK3,
LYN,
PTP2C,
PTPRA,
PTPRA,
PTPRE,
PTPRC,
PTPRC,
PTPRC,
PTPRG,
SKAP55,
SLP65,
Src, and
VAV1.
References
External links
Further reading
Category:Oncogenes/******************************************************************************* 01e38acffe
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ITS PLC Professional Edition is an education and training tool for PLC programming. Based on the latest PC technology, ITS PLC makes PLC training easy and fun. Learn basic and advanced technologies to train your clients. ITS PLC Professional Edition is the perfect tool for education in the field of automation, control, or data acquisition.
its plc professional edition activation key
ITS PLC Professional Edition is an education and training tool for PLC programming. Based on the latest PC technology, ITS PLC makes PLC training easy and fun. Based on the latest PC technology, ITS PLC makes PLC programming easy and fun. Learn basic and advanced technologies to train your clients. ITS PLC Professional Edition is the perfect tool for education in the field of automation, control, or data acquisition.
ITS PLC Professional Edition is an education and training tool for PLC programming. Based on the latest PC technology, ITS PLC makes PLC programming easy and fun. Based on the latest PC technology, ITS PLC makes PLC programming easy and fun. Learn basic and advanced technologies to train your clients. ITS PLC Professional Edition is the perfect tool for education in the field of automation, control, or data acquisition.
ITS PLC Professional Edition is an education and training tool for PLC programming. Based on the latest PC technology, ITS PLC makes PLC programming easy and fun. Based on the latest PC
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